The article covers the problem of students’ professional activity training in the Higher Medical School and psycho-pedagogical conditions of their learning activity on the basis of the systems and activity approach. The article describes a new pedagogical means — “the activity reference scheme”, presenting the material of all theoretical and practical disciplines as the integral system with its structure and contents. The article tells about students’ professional activity training, organized on the basis of “the activity reference scheme” of system type, that develops clinic (system) thinking.

The article under consideration deals with the problems of personalized approach to the assessment of the androgenic status of men with ramex.

New ways of treatment of chronic prostatitis as prevention of development of prostatic hyperplasia are described in this article. 

The characteristic features of neurogenic disfunctions of lower urinary tract are analized in this article.

Primary headache associated with sexual activity (PHASA) is a form of primary headaches, precipitated by sexual activity, in the absence of any intracranial disorder. Two types of PHASA are discerned: preorgasmic and orgasmic. A case of 44 years old patient with orgasmic headache is presented. Principles of differential diagnosis of orgasmic headache with secondary headaches and management of patients with PHASA are discussed.

This paper is devoted to the application of epithelial monolayer of human colon adenocarcinoma cells — Caco-2 for in vitro permeability evaluation of drugs. Main advantages of this biological model are described. General principles, approaches and methodology of Caco-2 permeability assay are defined. Correlation between human intestinal permeability in vitro and apparent permeability coefficient in vitro is indicated

This article provides a brief outline of the history and teaching of the discipline "Toxicological Chemistry" on the chair of pharmaceutical and toxicological chemistry of the First MSMU named after M.I. Sechenov.

This article discusses the possibility of clinical research of drugs, identifies the specific features of the phase I of clinical investigations.

The method of express detection of hypotensive drugs (atenolol, propranolol, nifedipine, enalaprile and verapamil) in urine samples of patients with acute poisonings was developed. The optimum conditions of group identification of hypotensive drugs using TLC were found. Analysis by GC-MS allows to detect both the native substances and their metabolites. The developed method of analysis of antihypertensive drugs can be used for the diagnosis of acute poisoning.

The methods for quantitative determination of thiamine in blood plasma by means of LC-MS method providing studies of bioequivalence are developed in this paper.

This article deals with current issues of pharmacotherapy of cardiovascular diseases which are based on disfunction of the renin-angiotensin-aldosterone system. As compared with the efficacy and safety of two major classes of drugs for the pharmacotherapy of cardiovascular diseases — angiotensin II receptor blockers and ACE inhibitors — are given data from clinical trials of both classes of drugs.