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Longitudinal co-evolution of human beings and pathogens resulted in polymorphism of Homo sapiens. CCR5Δ32 HIV-resistance allele is the exception to the rules. Recent origin of HIV-1 in Africa contradicted with the appearance of CCR5Δ32 allele in Northern Europe in previous ages. The author proposed non-contradictory theory of primary appearance of ancient HIV-1 in the Northern Europe 7–10 thousand years ago. The primary epidemics of HIV-infection had been stopped by the appearance of CCR5Δ32 mutation among the affected population. Reemergence of HIV-1 nowadays resulted by the penetration of hibernated HIV-1 into population of drug addicts and men having sex with men.

About the Author

V. P. Sergiev
The I.M. Sechenov First MSMU
Russian Federation

Vladimir Petrovich Sergiev, MD, academician of RAMS, prof., head of the chair of tropical medicine and parasitic diseases, director of the Research Institute of medical parasitology and tropical medicine named after E.I. Martsinovsky

20 M. Pirogovskaya str., Moscow, 119435

Tel.: 8 (499) 246–80–49


1. Abrashkin A.A. Ancient civilizations of Russian plains. M.: Eksmo. 2012. 320 p.

2. Belyakov V.D., Golubev D.B., Kaminsky G.D., Tets V.V. Self-regulation of parasitic systems (molecular genetic mechanism). L.: Medicina. 1987. 240 p.

3. Bobkova M.R. Molecular genetic methods in the study of the epidemiology of infections that are transmitted by the parenteral route. Doctoral diss. abstract. M. 2002. 42 p.

4. Briko N.I., Zueva L.P., Pokrovsky V.I., Sergiev V.P., Shkarin V.V. Epidemiology. Textbook: in 2 vol. M.: MIA. 2013. 1488 p.

5. Wood M. In search of first civilizations. M.: STOLICA-PRINT. 2007. 288 p.

6. Kofiadi I.A., Khaitov R.M., Alekseev L.P., Sidorovich I.G., Karamov E.V. Immunogenetics of human sensitivity and resistance to HIV / AIDS // Fiziol. i patol. immun. sist. 2009; 13: 3–9.

7. Petrukhin V.Ya. Myths of Ancient Scandinavia. M.: AST. 2011. 463 p.

8. Prozorov L.Z. Pagan Rus’. M.: Yauza-press. 2011. 542 p.

9. Sergiev V.P. Human disease as a reflection of interspecies struggle. M.: Russkij vrach. 2003. 56 p.

10. Sergiev V.P., Filatov N.N. Man and his parasites: rivalry genomes and the molecular interaction. M.: Nauka. 2010. 398 p.

11. Scherbakov A.M., Ozereckovskaya N.N., An’ Ch.K., Fan V.T., Maj N.T.N. et al. Comparative characteristics of the flow of tropical malaria in individuals with and without drug addiction // Med. parazitol. 1985; 4: 25–27.

12. Apetrei C., Robertson D.L., Marx P.A. The history of SIVS and AIDS: epidemiology, phylogeny and biology of isolates from naturally SIV infected non-human primates (NHP) in Africa // Front. Biosc. 2004; 4: 225–254.

13. Aufderhaide A.C., Salo w., Madden M. A 9000-year record of Chagas’ disease // Proc. N. Acad. Sc. USA. 2004; 101: 2034–2039.

14. Bramanti B., Hummel S., Chiarelli B., Herrman D. Ancient DNA analysis of the Delta F508 mutation // Human Biology. 2003; 75: 105–115.

15. Bramanti B., Thomas M.G., Haak w., Unterlaender M., Jores P., Tambets K., Antanaitis-Jacobs I., Haidle M.N., Jankaikas R., Kind C.J., Lueth F., Terberger T., Hiller J., Matsumura S., Forster P., Burger J. Genetic discontinuity of local hunter-gatherers and central Europe’s first farmers // Science. 2009; 326 (5949): 137–140.

16. Capasso L. Brucellosis at Herculaneum 79 (AD) // Int. J. Osteopathology. 1999; 9: 277–288.

17. Carter R., Mendis K.N. Evolutionary and historical aspects of the burden of malaria // Clin. Microbiol. Rev. 2002; 14: 564–594.

18. Durand P.M., Coetzer T.L. Hereditary red cell disorders and malaria resistance // Haematologica. 2008; 93: 961–963.

19. Formaciari G., Gluffra V. The «gout of the Medici» making the modern diagnosis using paleopathology // Gene. 2013; 528: 46–50.

20. Formaciari G., Lavaglia K., Giusti L. Yuman papillomavirus in a 16-th century mummy // Lancet. 2003; 362: 1160.

21. Galvani A.P., Slatkin M. Evaluation plague and smallpox as historical selective pressure for CCR5-Δ32 HIV-resistance allele // Proc. Nat. Acad. Sc. USA. 2003; 100: 15276–15279.

22. Haak w., Forster P., Bramanti B., Matsumura S., Drandt G., Tanzer M., Villems R., Refrew C., Gronenborn D., Alt K.w., Burger J. Ancient DNA from first European farmers in 7500-year-old Neolithic site // Science. 2005; 310 (5750): 1016–1018.

23. Haldane J.B.S. Disease and evolution // Ric. Scient. Suppl. 1949; 18: 68–76.

24. Hummel S., Schmidt D., Kremeyer D., Herrmann B., Oppermann V. Detection of the CCR5-Delta32 HIV resistance gene in Bronze Age skeletons // Genes Immunol. 2005; 6: 371–374.

25. Hyde J.T. Molecular parasitology. Buckingham: Open University Press, 1990. 302 p.

26. Lachman H.M. Battle of the genomes. Struggle for survival in a microbial world. Enfield: Science Publishers. 2006. 334 p.

27. Lacotte G., Mercier G. Distribution of the CCR5 gene 32 deletion in Europe // J. Acquire. Immune Dific. Syndr. Hum. Retrovirol. 1998; 19: 174–177.

28. Lederberg J. Infectious diseases as an evolutionary paradigm // Emerg. Infect. Dis. 1997; 3: 417–423.

29. Liber F., Cochaux P., Beckman G., Samson M., Aksenova M. et al. The Δccr5 mutation conferring protection against HIV-1 in Caucasian population has a single and recent origin in Northeast Europe // Hum. Mol. Genet. 1998; 7: 399–406.

30. Limbovska S.A., Balanovsky O.P., Balanovskaya E.V., Smolinsky P.A., Achadrina M.I. Analysis of CCR5Delta32 geographic distribution and its correlation with some climatic and geographical factors // Hum. Hered. 2002; 53: 49–54.

31. Marx P.A., Apetrei C., Drucker E. AIDS as a zoonosis? Confusion over the origin of the virus and the origin of the epidemics // J. Med. Primatol. 2004; 33: 220–226.

32. McNeill w.H. Plagues and people. Harmondsworth: Penguin Books Ltd. 1976. 330 p.

33. Minozzi S., Catalano P., Caldari C., Fornaciari G. Paleopathology of human remains from the Roman Imperial Age // Pathobiology. 2012; 79: 268–283.

34. Neel C., Etienne L., Li Y., Rudicell R.S., Bass I.N. Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas // J. Virol. 2010; 84: 1464–1476.

35. Nielsen R., Bustamante C., Clark A.G., Glanowski S. A scan for positively selected genes in the genomes of humans and chimpanzees // PloS Biol., 2005; 3: 179–179.

36. November J., Galvani A.P., Slatkin M. The geographical spread of the CCR5 Δ32 YIV-resistance allele // PLoS Biol. 2005; 3: 1954–1963.

37. Poolman E.M., Galvani A.M. Evaluating candidate agents of selective pressure for cystic fibrosis // J. R. Soc. Interface. 2007; 4: 91–98.

38. Sabeti P.C., walsh E., Schaffner S.F., Varilly P., Fry D. The case for selection at CCR5-Δ32 // PLoS. Biol. 2005; 3: 1963–1969.

39. Sahly el H.M., Reich R.A., Jun Dou S., Musser J.M., Graviss E.A. The effect of mannose binding lectine gene on susceptibility to tuberculosis in different ethnic group // Scan. J. Infect. Dis. 2004; 36: 106–108.

40. Sallares R. Pathocoenoses ancient and modern // Hist. Phil. Life Sc. 2005; 27: 201–220.

41. Salemi M., Strimmer K., Hall w.w., Duffi M., Delaporte E. Dating the common ancessor of SIVcpz and HIV-1 group M and the origin of HIV-1 subtypes using a new method to uncover clock-like molecular evolution // FASEB J. 2001; 2: 276–278.

42. Stephens J.C., Reich D.E., Goldstein D.B., Shin H.D., Smith M.w. Dating the origin of the CCR5Δ32 AIDS-resistance allele by the coalescence of haplotypes // Am. J. Hum. Genet. 1998; 62: 1507–1515.

43. Taboga-Venegas N., Zapata w., Rugeles M.T. Genetic and immunological factors involved in natural resistance to HIV-1 infection // Open Vir. J. 2011; 5: 35–43.

44. Takehisa J., Kraus M.H., Ayouba A., Bailes E., Van Heuverswyn F. Origin and biology of simian immunodeficiency virus in wild-living western gorillas // J. Virol. 2009; 83: 1635–1648.

45. Taylor G., Rutland P., Molleson T. A sensitive polymerase chain reaction method for the detection of Plasmodium species DNA in ancient human remains // Ancient Biomolecules. 1997; 1: 193–203.

46. White E., Brown D.M. The first men. Nederland: Time-Life Intern. 1973. 354 p.

47. Wooding S., Stone A.C., Dunn D.M., Mummidi S., Jorde L.B. Contrasting effect of natural selection on human and chimpanzee CC chemokine receptor // S. Am. J. Hum. Genet. 2005; 76: 291–301.


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