克罗恩病在三个亲生兄弟中的临床表现及病程发展的特征

摘要
遗传性前置因素是家庭中兄弟姐妹克罗恩病（CD）的最重要的风险因素。
病例报告
在一个有6个子女的家庭中，有3个兄弟被诊断出克罗恩病：其中一个年龄为15岁，另外两个17岁。最为年长的哥哥克罗恩病表现为急性肠梗阻，回肠穿孔，弥漫性腹膜炎。排行第二的哥哥，其症状与阑尾浸润类似。上述两名兄弟均接受了回肠末端，盲肠和部分升结肠切除并进行了回肠上腹吻合术。最年幼的弟弟被诊断出克罗恩病但并不伴有肠狭窄及肠穿孔，，且发病缓慢，无并发症。在没有克罗恩病的兄弟姐妹中，有两人患有类风湿性关节炎和白癜风。
讨论：
发病年龄较年轻，回肠及大肠同时受损是家族型克罗恩病的相似特征; 而差异性特征在于，只有两个兄弟存在并发症并进行了外科手术。该病例报告特殊性在于，患克罗恩病的仅有男孩，且在这同一代兄弟姐妹中同时存在三种不同的自身免疫性疾病。

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