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The methods of assessment of quality and safety of medicaments on the basis of low molecular weight heparins

Abstract

To consider the methods for assessing quality and safety of drugs on the basis of low molecular weight heparin.

About the Authors

E. A. Arianova
First MSMU named after I. M. Sechenov
Russian Federation

post-graduate student of the chair of pharmaceutical chemistry with a course of toxicological chemistry



M. N. Bogachuk
First MSMU named after I. M. Sechenov
Russian Federation

post-graduate student of the chair of pharmaceutical chemistry with a course of toxicological chemistry



O. I. Perederyaev
First MSMU named after I. M. Sechenov
Russian Federation

PhD, lecturer of the chair of pharmaceutical chemistry with a course of toxicological chemistry



References

1. Селеменев В.Ф., Хохлова О.Н., Хохлов В.Ю., Щербинин Р.Л. Определение гепарина спектрофотометрическим и фотоколориметрическим методами // Химико-фармацевтический журнал. 1999. № 8. С.47–48.

2. Rahul P. Patel, Christian Narkowicz, Glenn A. Jacobson. Effective reversed-phase ion pair high-performance liquid chromatography method for the separation and characterization of intact low-molecular-weight heparins // Analytical Biochemistry. 2009. V.387. P. 113–121.

3. Pierre A.J. Mourier, Christian Viskov. Chromatographic analysis and sequencing approach of heparin oligosaccharides using cetyltrimethylammonium dynamically coated stationary phases // Analytical Biochemistry. 2004. V. 332. P. 299–313.

4. Romain R. VIVE, Sarah GOODGER and David A. PYE // Combined strong anion-exchange HPLC and PAGE approach for the purification of heparan sulphate oligosaccharides // Biochem. J. 2001. V.354. P.141–147.

5. Stacie L. Eldridge, Albert K. Korir, Sarah M. Gutierrez et al. Heterogeneity of depolymerized heparin SEC fractions: to pool or not to pool? // Carbohydrate Research. 2008. V. 343. P. 2963–2970.

6. Andr´e Ziegler, Joseph Zaia. Size-exclusion chromatography of heparin oligosaccharides at high and low pressure. // Journal of Chromatography B. 2006. V. 837. P. 76–86.

7. Timothy King J., Umesh R. Desai. A capillary electrophoretic method for fingerprinting low molecular weight heparins // Analytical Biochemistry. 2008. V. 380. P. 229–234.

8. Peter Mikus, Iva Valaskova, Emil Havranek. Analytical characterization of heparin by capillary zone electrophoresis with conductivity detection and polymeric buffer additives // Journal of Pharmaceutical and Biomedical Analysis. 2004. V. 36. P. 441–446.

9. Kevin G. RICE, Marry K. ROTTINK, Robert J. LINHARDT. Fractionation of heparin-derived oligosaccharides by gradient polyacrylamide-gel electrophoresis // Biochem. 1987. V. 244. P. 512–522.

10. Tanja Beyer, Magnus Matz, Daniela Brinz et al. Composition of OSCS-contaminated heparin occurring in 2008 in batches on the German market // European Journal of Pharmaceutical Sciences. 2010. V. 40. Is. 4. P.297–304.

11. David A. Keire, Michael L. Trehy, John C. Reepmeyer. Analysis of crude heparin by 1H NMR, capillary electrophoresis, and strong-anion-exchange-HPLC for contamination by over sulfated chondroitin sulfate // Journal of Pharmaceutical and Biomedical Analysis. 2010. V. 51. P. 921–926.

12. Michael L. Trehy, John C. Reepmeyer, Richard E. Kolinski, Benjamin J.Westenberger, Lucinda F. Buhse. Analysis of heparin sodium by SAX/HPLC for contaminants and impurities // Journal of Pharmaceutical and Biomedical Analysis. 2009. V. 49. P. 670–673.

13. Shawn Bairstow, JeffMcKee, Mark Nordhaus, Richard Johnson. Identification of a simple and sensitive microplate method for the detection of oversulfated chondroitin sulfate in heparin products // Analytical Biochemistry. 2009. V. 388. P. 317–321.


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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)