Sechenov Medical Journal

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No 3-4 (2011)
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4-13 35

The content of vitamins and relative biologically active substances including the products of lipids peroxidation has been studied in the blood of 115 males -patients of Department of Urology of I.M.Sechenov First Moscow State Medical University. The patients have been divided to four groups: prostatic carcinoma (PC); high grade prostatic intraepithelial neoplasia (HG PIN) or precancer; mixed group of conditional control – low grade PIN, benign prostatic hyperplasia, chronic prostatitis or their combination; control group of healthy men without prostate pathology. Further statistically reliable differences have been found: patients with PC had lower level of antioxidants – lycopene, vitamin E and enhanced level of diene conjugates (products of lipid peroxidation); patients with HG PIN low level of vitamin C, total carotenoids and increased diene conjugates. The difference in vitamins-antioxidants levels in patients with PC and HG PIN has not been found out.


14-19 25

The article deals with the history of the formation of the legal and regulatory basis of the Russian Federation, which regulates the position of HIV-infected, starting with the repressive measures in the 80 years of the 20-th century and following the progress made up to the contemporary moment of time with quite a wide range of human rights and social guarantees which are given to that category of citizens.


20-23 44

To consider the methods for assessing quality and safety of drugs on the basis of low molecular weight heparin.

24-30 24

Scribes development and validation of HPLC method with UV detection at 260 nm for determination of tenofovir in rabbit plasma. Plasma samples were treated by protein precipitation using methanol. HPLC analysis was performed on Waters Atlantis T3 column (5 μm, 4,6 x 150 mm), with precolumn Waters Atlantis T3 (5 μm, 4,6 x 20 mm). Acetonitrile –phosphate buffer pH 5.70 (16:84) at 1.0 mL/min was used as mobile phase. The standard curve was linear over the range 0.23 μg/ml to 112,98 μg/ml of tenofovir in plasma. Method precision (RSD, %) was 6.08 % to 12.36 % determined on spiked samples. The accuracy of the method (ε, %) was – 2.96 % to 14.55 %. The lower limit of quantification was 0.23 μg/ml. The method was applied to preclinical pharmacokinetics study of tenofovir drug products in rabbits.

31-38 67

Paper Standardization of herbal drugs, containing iridoids (review) describes comparative analysis of methods, used for Tests (TLC, macrochemical reactions) and Assay of herbal drugs in main Pharmacopoeias (U.S. Pharmacopoeia USP 33–NF 28, European Pharmacopoeia 7.0, Russian State Pharmacopoeia XI-XII, British Pharmacopoeia 2007). Recommendations for using of modern methods of iridoids identification and assay in herbal drugs for development of Russian pharmacopoeial monographs are given.


39-42 39

The purpose of this study was to identify anatomic variations of the structure of urethrovesical segment in young men. Seized 60 urethrovesical segment the corpses of young men belonging to different somatotype. Carried out an anthropometric survey of men and makroanatomic study urethrovesical segment. The results obtained demonstrated the constitutional structure of the urethrovesical segment dependence in young men.


43-52 55

Evolution of the approaches to diagnostics of DUI as the evidentiary base in law violations is traced; parallelism in the development of scientific beliefs on the nature of acute alcohol intoxication, scientific and technological achievements – on one hand, and legislation in the field of traffic safety, on the other is described Two principles of diagnostics are compared – clinical and chemical-toxicological, their advantages and disadvantages. Author’s point of view concerning optimal principles of diagnostics and legislation in Russia is formulated.


53-59 30

Тhe paper of Shohin I.E., Ramenskaya G.V., Medvedev Yu.V., Yarushok T.A., Sheveleva M.A.1 is devoted to development and validation of HPLC method determination of topiramate in rabbit plasma with precolumn derivatization. Topiramate was extracted from plasma by dichloromethane. Derivatization was performed by dansyl chloride in borate buffer. HPLC analysis was performed on C18 column (3 μm, 4,6 x 75 mm). Acetonitrile – 25 mM phosphate buffer pH 2.50 (30:70) at 1.0 mL/min was used as mobile phase. The standard curve was linear over the range 0.95 μg/ml to 47.32 μg/ml of topiramate in plasma. Within-run precision was 1.55 % to 2.12 % and between-run precision was 1.67 % to 8.09 % determined on spiked samples. The accuracy of the method was 1.14 % to 19.62 % (within-run) and 1.74 % to 19.25 (between-run). The lower limit of quantification was 0.95 μg/ ml. The method was applied to preclinical pharmacokinetics study of topiramate drug products in rabbits.

60-70 24

On materials of sociological empirical research of two universities of Russia (2006 – 2010) necessity of formation of a social role of the doctor-teacher, support and its regulation new possibilities, maintenance of variants of realization of social and professional potential of doctors-teachers, their adaptation to sociologopedagogical innovations is tracked.


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ISSN 2218-7332 (Print)
ISSN 2658-3348 (Online)